2-[[[4-(3-METHOXYPROPOXY)-3-METHYL-2-PYRIDINYL]METHYL]SULFINYL]-1H-BENZIMIDAZOLE, SODIUM SALT
Rebeprazole sodium
CAS: 117976-90-6
Molecular Formula: C18H20N3NaO3S
2-[[[4-(3-METHOXYPROPOXY)-3-METHYL-2-PYRIDINYL]METHYL]SULFINYL]-1H-BENZIMIDAZOLE, SODIUM SALT - Names and Identifiers
| Name | Rebeprazole sodium |
| Synonyms | PARIET RABEPRAZOL SODIUM SODIUM RABEPRAZOLE RABEPRAZOLE SODIUM Rebeprazole sodium rebeprazole sodium RABEPRAZOLE, SODIUM SALT (3,5-dibromo-4-hydroxyphenyl)(2-ethyl-1-benzofuran-3-yl)methanone sodium 2-[[4-(3-methoxypropoxy)-3-methyl-pyridin-2-yl]methylsulfinyl]benzoimidazole [2-[[4-(3-methoxypropoxy)-3-methyl-2-pyridyl]methylsulfinyl]benzimidazol-1-yl]sodium sodium 2-({[4-(3-methoxypropoxy)-3-methylpyridin-2-yl]methyl}sulfinyl)benzimidazol-1-ide 2-[[[4-(3-METHOXYPROPOXY)-3-METHYLPYRIDIN-2-YL]METHYL]SULFINY]-1H-BENZIMIDAZOLE SODIUM SALT 2-[[[4-(3-METHOXYPROPOXY)-3-METHYL-2-PYRIDINYL]METHYL]SULFINYL]-1H-BENZIMIDAZOLE, SODIUM SALT |
| CAS | 117976-90-6 |
| EINECS | 629-730-3 |
| InChI | InChI=1/C18H20N3O3S.Na/c1-13-16(19-9-8-17(13)24-11-5-10-23-2)12-25(22)18-20-14-6-3-4-7-15(14)21-18;/h3-4,6-9H,5,10-12H2,1-2H3;/q-1;+1/rC18H20N3NaO3S/c1-13-15(19-9-8-17(13)25-11-5-10-24-2)12-26(23)18-20-14-6-3-4-7-16(14)21(18)22/h3-4,6-9H,5,10-12H2,1-2H3 |
| InChIKey | KRCQSTCYZUOBHN-UHFFFAOYSA-N |
2-[[[4-(3-METHOXYPROPOXY)-3-METHYL-2-PYRIDINYL]METHYL]SULFINYL]-1H-BENZIMIDAZOLE, SODIUM SALT - Physico-chemical Properties
| Molecular Formula | C18H20N3NaO3S |
| Molar Mass | 381.42 |
| Melting Point | 140-141°C dec. |
| Boling Point | 603.9°C at 760 mmHg |
| Solubility | Easily soluble in water or methanol, easily soluble in absolute ethanol or ethyl acetate, almost insoluble in ether or ethane. |
| Appearance | White or off-white crystalline powder |
| Color | white to beige |
| Merck | 14,8089 |
| Storage Condition | -20°C |
| Stability | Hygroscopic |
| MDL | MFCD02092688 |
| In vitro study | Treatment of MKN-28 cells with rabeprazole will significantly reduce their viability. Rabeprazole induced massive apoptosis in AGS cells and competitively inhibited the phosphorylation of ERK1/2 in MKN-28 cells, whereas this effect was absent in KATO III or MKN-45 cells. Rabeprazole can effectively inhibit the phosphorylation of ERK1/2 in gastric cancer cells, and weaken the viability of human gastric cancer cells by inhibiting the ERK1/2 signaling pathway. |
| In vivo study | In rats after Subtotal gastrectomy, Rabeprazole did not worsen the disturbance of bone metabolism, but improved the TG-induced decrease in bone density. |
2-[[[4-(3-METHOXYPROPOXY)-3-METHYL-2-PYRIDINYL]METHYL]SULFINYL]-1H-BENZIMIDAZOLE, SODIUM SALT - Risk and Safety
| WGK Germany | 3 |
| HS Code | 2933399090 |
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